Open access
Sep 2026
Mechanism of gating and isoform-specific inhibition in renal CLC chloride channels.
Hyponatremia is a prevalent disorder marked by excess water retention and substantial morbidity, motivating interest in the chloride channel CLC-Ka as a therapeutic target. Selectively inhibiting CLC-Ka without affecting the closely related CLC-Kb is essential for preventing serious side effects. However, developing is...
Chih-Ta Chien, Briana L. Sobecks-Doherty, A. Powers et al.
· Proceedings of the National... · 0 citations