Author

Andrew J Stagg

2 papers indexed here

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Open access Nov 2026

Fungal suppression by bacterial metabolite-activated human intestinal γδT-cells is disrupted in Crohn's disease.

Gut symbionts condition mucosal immunity to resist infection by enteropathogens, but the specific microbes and mechanisms involved differ significantly between host species. In higher primates, bacterial metabolite HMB-PP is sensed by a specialized population of Vγ9Vδ2+T-cells, which we now report can potently suppress...

L. Mathew, S. Carlson, M. Savage et al. · PLoS Biology · 0 citations

Open access Aug 2026

Systemic reprogramming of monocytes in Crohn’s disease promotes their intestinal inflammatory function

Bone marrow–derived circulating monocytes continuously replenish intestinal macrophages, which become dysregulated in inflammatory bowel disease (IBD) and contribute to disease pathology. The origins of this dysregulation remain poorly understood. Here, we investigate the reprogramming of circulating monocytes in IBD p...

E. Hornsby, Radha Gadhok, I. Hoti et al. · JCI Insight · 0 citations