Author

Andrew L. Kung

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Sep 2026

Abstract IA02: Single-cell regulatory network analysis of therapy-associated cell state remodeling to inform combination strategies in osteosarcoma

Intratumor heterogeneity and plasticity contribute to resistance, as coexisting tumor cell states exhibit non-overlapping drug sensitivities and divergent responses to therapy. Combination therapy design thus requires identifying vulnerabilities of treatment-persistent populations and measuring state-specific drug ef...

Jovana Pavisic, Chelsey M. Burke, Dao-Qi You et al. · Cancer Research · 0 citations

Open access Jul 2026

IL7-Receptor–Targeted CAR T-Cell Therapy for T-Cell Acute Lymphoblastic Leukemia

The authors propose IL7-Receptor (IL7R/CD127) as an alternative target for T-ALL and propose IL7-Receptor/CD127 CAR-T cells as an alternative target for T-ALL, showing the antitumor efficacy of IL7Rα/CD127 CAR-T cells against T-ALL in preclinical models.

H. Hocine, Undrakh Ganbaatar, Alfredo Amador-Molina et al. · Nature Communications · 0 citations