Single-cell T cell receptor (TCR) repertoire sequencing enables simultaneous profiling of gene expression and TCR sequences, providing a coregistered measure of T cell phenotypic diversity and clonal dynamics. However, principled probabilistic frameworks for joint modeling of clonotype and phenotype have remained limit...
N. Ceglia, Sohrab Salehi, Z. Sethna et al.· Nature Genetics· 0 citations
Extrachromosomal DNA (ecDNA) comprises megabase-sized circular DNA elements that frequently carry oncogene amplifications, driving aggressive tumour phenotypes, therapeutic resistance and poor clinical outcomes across many cancers1, 2, 3–4. Although ecDNA is thought to arise from canonical double-strand break repair, t...
David Billing, Monica Selvaraj, M. E. Kelley et al.· Nature· 1 citation
A recurrent AML dark proteome is defined and a framework for the discovery of tumor-specific non-canonical proteins for mechanistic and therapeutic studies is established.
L. Schmalbrock, Asher Preska Steinberg, Katarzyna Kulej et al.· bioRxiv· 0 citations
A large-scale international programme—the Human Cancer Models Initiative—is presented, which involved the generation of a resource of 665 next-generation models from 2,780 donors with 25 cancer types and integrated tumour–model whole genome, exome, methylome and transcriptome analyses.
Dina Elharouni, Mushriq Al-Jazrawe, Seongmin Choi et al.· Nature· 7 citations
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