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Author

Andrew Norris

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Jul 2026

Abstract A080: Activation of hSSB2/1 by BCN077 Induces Tumor-Selective Mitotic Catastrophe While Protecting Irradiated Epithelium: A New Therapeutic Paradigm for Expanding the Cancer Treatment Window

Findings support a mechanism in which hSSB2 activation intensifies genotoxic stress beyond the tolerable threshold in cancer cells while reinforcing recovery and survival programs in normal tissues, representing a genuine translational opportunity to expand the therapeutic window of radiation and chemotherapy.

Andrew Norris, Elizabeth M. Singer, R. Chugh et al. · 0 citations

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