Abstract A080: Activation of hSSB2/1 by BCN077 Induces Tumor-Selective Mitotic Catastrophe While Protecting Irradiated Epithelium: A New Therapeutic Paradigm for Expanding the Cancer Treatment Window
Findings support a mechanism in which hSSB2 activation intensifies genotoxic stress beyond the tolerable threshold in cancer cells while reinforcing recovery and survival programs in normal tissues, representing a genuine translational opportunity to expand the therapeutic window of radiation and chemotherapy.