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A theoretical framework comparing Darwinian, Lamarckian, and agent-directed evolution following environmental change is developed, to preserve humanity's ability to guide its direction, limit its speed, and intervene when necessary.
Around a quarter of drug development now has a Chinese origin, yet China-specific success benchmarks and forecasting tools remain scarce. We analyze all nongeneric drug trials registered on China's national drug clinical trial registry from 2013 to 2025, benchmark phase-transition probabilities of success (PoS)-where s...
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