Open access
Aug 2026
An expanded codebook of human transcription factor DNA-binding specificity
Gene expression is regulated by transcription factors (TFs), which recognize specific DNA sequence motifs. Several hundred putative human TFs, identified mainly by an apparent DNA-binding domain, lack known binding motifs1. Furthermore, even for well-characterized TFs, it remains controversial the degree to which motif...
A. Jolma, Kaitlin U. Laverty, Ali Fathi et al.
· Nature · 3 citations