The Critical Clock: Time-Dependent Inflammation, Catabolism and Immunosuppression Syndrome Is Associated with ICU Mortality
Background/Objectives: Chronic critical illness (CCI) is increasingly recognized as a major challenge in intensive care, yet its definition remains heterogeneous. The triad of inflammation, catabolism, and immunosuppression (ICS) is central to proposed CCI pathophysiology, but the association between its changing compo...