Author

Aneta Jurkiewicz

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Oct 2026

The IKK complex and TBK1/IKKε are recruited to STING through distinct mechanisms to activate NF-κB signaling.

Stimulator of interferon genes (STING) is a highly conserved signaling molecule that coordinates an antiviral innate immune response through activation of the nuclear factor κB (NF-κB) and interferon regulatory factor 3 (IRF3) signaling pathways. In addition to an antiviral response, STING-mediated NF-κB signaling also...

A. Christensen, Aneta Jurkiewicz, Cathrine Silberbauer Jensen et al. · Science immunology · 0 citations

Open access Aug 2026

TTC33 forms a complex with WDR61 and PHF5A to recruit factors relevant to genomic integrity

Using a combination of biochemical assays, structural modeling and molecular dynamics, it is shown that TTC33 directly recruits WDR61 and PHF5A to assemble into a trimeric core complex (TANC), which then forms distinct interactions with either UNG1/2 or SF3B–CCDC97.

R. Tomecki, Małgorzata Drabko, Małgorzata Siek et al. · Nature Communications · 0 citations