Open access
Jul 2026
Octameric dGTPase assemblies mediate broad anti-phage defense
Deoxyguanosine triphosphatases (dGTPases) are nucleotide-depleting enzymes known to play a role in antiviral defense. While their enzymatic mechanism is established, the structural and functional diversity of dGTPases remains poorly understood. Here, we report a systematic analysis of dGTPase homologs across bacteria,...
Miao Shi, Peipei Li, Quanjin Li et al.
· Nature Communications · 0 citations