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Author

Ang Zhou

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Open access Aug 2026

Mitochondrial stress activates ELT-2–dependent lysosomal proteostasis to extend lifespan in C. elegans

It is shown that inhibition of mitochondrial respiration induces a sustained transcriptional program that enhances lysosomal proteolysis during aging in Caenorhabditis elegans and reveals a previously unrecognized ELT-2–dependent lysosomal proteostasis pathway that acts downstream of mitochondrial stress to maintain pr...

Rendan Yang, Yu Sun, Wen-Zheng Wang et al. · 0 citations

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