Angavai Swaminathan

A bacterial metabolite rewires fungal metabolism, triggering the hyphae-to-yeast transition.

Fungi transition between cell morphologies to adapt to and colonize environments. For Candida albicans, commensal colonization of humans and virulence depend on a reversible switch between invasive hyphae and disseminating yeast cells. The yeast-to-hyphae transition is well understood, but comparatively little is known...