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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Angela Wu

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Open access Aug 2026

A Conserved Flexible N-Terminal Domain Tunes the Calcium Sensitivity of Sorcin by Stabilizing Its Active Conformation

Sorcin is a penta-EF-hand Ca2+-binding protein that acts as a Ca2+ sensor and regulator of Ca2+ homeostasis. Although the structure and Ca2+-dependent activation of Sorcin is well characterized, the function of its flexible N-terminal domain (NTD) remains unclear. We combined sequence analysis, Ca2+-induced aggregation...

Qiushi Ye, Angela Wu, K. Carillo et al. · 0 citations
Open access Aug 2026

Machine Learning-Guided Design of Novel Janus Kinase Inhibitors for Rheumatoid Arthritis Treatment

Attenuation of autoimmune responses by inhibiting immune activation pathways has been a common strategy for treating autoimmune diseases. The inhibition of JAK2 protein has proven effective in a clinical setting for treating RA. However, most of the JAK inhibitors have limited isoform selectivity, resulting in broad im...

Angela Wu · 0 citations

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