Electron Paramagnetic Resonance (EPR) Spectroscopy Reveals Nucleotide- and Partner-Dependent Conformational Ensembles in Hsp90
These studies establish EPR spectroscopy as a valuable biophysical tool for resolving conformational ensembles and structural heterogeneity underlying Hsp90’s function, with general relevance to the structural biology, spectroscopy, and chaperone fields, and pave the way for future in vitro and in-cell investigations o...