Author

Angelo D’Alessandro

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Open access Aug 2026

Structural and Functional Interrogation of Active Streptococcus pneumoniae Sortase A

Sortase A (SrtA) enzymes covalently anchor surface proteins to Gram-positive bacterial cell walls, promoting colonization and virulence. In Streptococcus pneumoniae, previous studies identified both a domain-swapped dimer and an active refolded monomer, but the active enzyme has not been characterized at the structural...

Eunjeong Lee, Blaine H. Gordon, J. Redzic et al. · Biomolecules · 0 citations