Rhodium-Catalyzed Asymmetric Hydroformylation of Vinyl Ethers as a Key Step in the Synthesis of Chiral Fine Chemicals
The rhodium-catalyzed asymmetric hydroformylation (AHF) of vinyl ethers provides a powerful synthetic step to yield chiral aldehydes as products or intermediates for industrially relevant fine chemicals. Out of the 40 chiral ligands tested, the phosphine-phosphorodiamidite (S,S,RP,S)-BettiPhos L7 and the phosphine-ph...