PP2Acα regulates the Hippo-YAP signaling axis to promote cardiac regeneration and alleviate myocardial infarction.
PP2Acα is identified as a critical phosphatase that promotes neonatal cardiac regeneration by directly dephosphorylating YAP and activating the Hippo-YAP signaling axis, uncovering a previously unrecognized regulatory mechanism controlling cardiomyocyte proliferation and highlighting a potential therapeutic target for...