Open access
Aug 2026
Heat Shock Protein Inhibitor Tanespimycin (17AAG) Suppresses SARS‐CoV‐2 Main Protease Activity and Is More Potent Than Clinically Approved Antiviral Nirmatrelvir
Data is presented showing that 17AAG covalently binds to the active‐site cysteine of Mpro, disrupts its secondary structure, and protects cells from Mpro‐induced toxicity more effectively than nirmatrelvir.
Gargi Mukherjee, Shayantani Chakraborty, Anshuman Chandra et al.
· ChemBioChem · 0 citations