Epigenetic Modification and Host Gene Silencing Profile Induced by High-Risk HPV Strains in Cervical Cancer
Persistent infection with high-risk human papillomavirus (HR-HPV) is the primary driver of cervical cancer; however, viral presence alone is insufficient to induce malignancy. The progression from initial infection to invasive carcinoma requires a coordinated series of alterations in both the viral genome and the host...