Open access
Sep 2026
Conformationally restrained de novo peptides to modulate Skp1-Skp2 interaction of the SCF E3 ligase.
De novo peptide sequences are introduced through in silico screening of a peptide pool to target the Skp1-Skp2 core interface and establish the potential of first-in-class peptides in targeting the Skp1-Skp2 interface for the treatment of cancers driven by Skp2.
Simran Tolani, N. M. Tripathi, H. Antil et al.
· RSC Medicinal Chemistry · 1 citation