Endothelial TLR4 coordinates angiogenesis and inflammation through a CXCR2-neutrophil-oxidative axis.
AIMS To determine the endothelial-intrinsic role of TLR4 in inflammatory vascular remodeling and cytokine signaling, and to define how exogenous microbial and oxidation-derived endogenous signals are integrated by endothelial TLR4 to regulate vascular function. METHODS AND RESULTS Single-cell transcriptomic analyses...