DEVELOPMENT OF OPTIMIZED ANTICANCER DRUG NANOCRYSTALS FOR ENHANCED CELLULAR INTERNALIZATION, BIOPHARMACEUTICAL PERFORMANCE AND IN-VITRO ANTICANCER ACTIVITY
Background: Cisplatin is an effective chemotherapeutic agent; however, its clinical application is limited by poor aqueous solubility, low cellular uptake, and suboptimal biopharmaceutical performance. Nanocrystal technology offers a promising strategy to overcome these limitations by enhancing dissolution and intracel...