A series of substituted indolo[2,1‐b]quinazoline‐6,12‐diones (SJ1‐SJ8), which consist of already published derivatives (SJ1‐SJ5) and newly synthesized derivatives (SJ6‐SJ8), has been studied for their possible α‐amylase inhibition property as an antidiabetic lead compound. The synthesized derivatives have been identifi...
Sahil Jaidka, Ankush Kumar, Christopher Basumatary et al.· Chemistry and Biodiversity· 0 citations
Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, represent chronic relapsing inflammatory disorders characterized by complex interactions among genetic, microbiome-related, immunological, and environmental factors. Although advances in biologics and small-molecule inhibitors have exp...
Priyanka Paul, Ankush Kumar, Rajwinder Kaur et al.· Current Medicinal Chemistry· 0 citations
Neolignans are potential natural product-derived anticancer leads; rational SAR-guided optimization, sophisticated delivery methods, and computational drug development may speed up their clinical translation.
Samarth Kumar, Ankush Kumar, Thakur Gurjeet Singh et al.· European journal of medicina...· 0 citations
Overall, pyridopyrimidine- and pyridopyrimidinones-based compounds continue to show great promise as potential anticancer agents and further research combining synthetic chemistry, biological studies, and computational approaches may lead to the development of more effective and safer drugs in the future.
Nanomedicine represents a promising approach for overcoming the limitations of conventional epilepsy therapy by enabling efficient brain-targeted drug delivery by enabling efficient brain targeting of antiepileptic drugs.
Abhishek Chauhan, Ankush Kumar, Ankit Awasthi et al.· The Journal of pharmacy and...· 0 citations
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