Open access
Sep 2026
Differential requirement for the Ire1 luminal domain in Candida albicans drug susceptibility and pathogenicity
The opportunistic human pathogen Candida albicans depends on the unfolded protein response (UPR) for cell wall integrity, antifungal tolerance, filamentous growth, and virulence. The UPR is driven by the conserved transmembrane sensor Ire1, which is activated either by misfolded proteins through its luminal domain or b...
Samuel Stack-Couture, Nathan Towriss, I. Skulska et al.
· bioRxiv · 0 citations