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Anna-Maria Dittrich

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Open access Oct 2026

Basal Cell Expansion Conditions Influence Differentiation and Phenotypic Outcomes in Primary Nasal Epithelia Grown at Air–Liquid Interface

Background/Objectives: Primary airway epithelia grown at air–liquid interface (ALI) are widely used to model respiratory endophenotypes and to enable individualized functional testing. However, culture conditions used to establish ALI vary considerably and may introduce selection biases. We aimed to adapt our lung expl...

S. Tamm, R. Dalferth, Long-Hua Feng et al. · 0 citations
Open access Oct 2026

Vanzacaftor/tezacaftor/deutivacaftor partially restores CFTR function of the L467F;F508del complex allele in primary nasal epithelial cells.

Highly effective CFTR modulator therapies have transformed the treatment of cystic fibrosis (CF). Elexacaftor/tezacaftor/ivacaftor (ETI) leads to restoration of CFTR-mediated chloride transport of around 40% of normal CFTR activity and results in substantial clinical benefits in people with CF and at least one F508del...

Jasmin Berger, A. Balázs, R. Dalferth et al. · 0 citations
Open access Jul 2026

Increased high sensitivity C-reactive protein in more severe wheeze/asthma phenotypes in child- and adulthood in ALLIANCE

HsCRP was increased in adult asthmatics compared to HCs and was associated with several severity-related clinical characteristics, whereas ICS use in preschool wheezers was associated with lower hsCRP levels.

Lena Lagally, Lena Ullemeyer, J. Omony et al. · 0 citations

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