Anna T. Nguyen

Myogenic dysregulation underlies human tongue overgrowth in Beckwith-Wiedemann syndrome

Summary Macroglossia is a clinically significant feature of Beckwith-Wiedemann syndrome (BWS), but the cellular basis of tongue overgrowth remains poorly defined. Using pediatric tongue specimens from molecularly defined BWS subtypes and age-matched nonBWS controls, we show that BWS macroglossia is characterized by ske...

Fibroadipogenic Progenitor Cells Contribute to Tongue Skeletal Muscle Hypertrophy in Beckwith-Wiedemann Syndrome