Author

Annabel J. Curle

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Open access Jul 2026

Activation of transposable elements is linked to a region- and cell type–specific interferon response in Parkinson’s disease

Parkinson’s disease (PD) is a neurodegenerative disorder involving a neuroinflammatory response, the cause of which remains unclear. Transposable elements (TE) have been linked to inflammation, but their potential role in PD remains unexplored. Using bulk- and single-nuclei RNAseq of postmortem brain tissue from four b...

R. Garza, Anita Adami, Arun Thiruvalluvan et al. · bioRxiv · 2 citations

Open access Sep 2026

BCOR mutations establish a persistent culture-adaptive state in human induced pluripotent stem cells

Human induced pluripotent stem cells (hiPSCs) are widely used for disease modelling and regenerative medicine, yet their utility depends on maintaining molecular integrity during long-term culture. BCOR (BCL6 Co-Repressor) mutations are among the most recurrent culture-acquired alterations in hiPSCs, but their function...

C. Badja, S. Boushaki, Yogesh Kumar et al. · bioRxiv · 0 citations