Author

Anthony A. Grace

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Editorial Sep 2026

Hippocampal mechanisms and neural circuitry of negative symptoms in schizophrenia.

Negative symptoms represent a debilitating core of schizophrenia symptomatology that fail to respond to treatment with D2 antagonist antipsychotic drugs and may even be exacerbated by D2 antagonism. The neurobiological mechanisms underlying these symptoms are proposed to be related to limbic hippocampal hyperactivity,...

D. Uliana, Anthony A. Grace · Schizophrenia Research · 0 citations

Review Jul 2026

Toward a Pluralistic Model for the Schizophrenia Spectrum-Dopamine and Beyond.

Dopaminergic hyperactivity may be a key mechanism for core psychotic symptoms in many patients, but it is unlikely that dopamine dysregulation is a universal final common pathway across symptom domains.

M. Keshavan, Henry A. Nasrallah, A. Abi-Dargham et al. · JAMA psychiatry · 0 citations