Whole-genome duplications (WGDs) profoundly shaped early vertebrate evolution. The set of paralogs retained from these events—“ohnologs”—has had lasting impacts on genome structure and function, including disease gene enrichment. Despite this, we still lack a gold standard ohnolog database. Here, we have harnessed ance...
Łukasz Niezabitowski, Róisín Long, Anthony K. Redmond et al.· Science Advances· 0 citations
Whole-genome duplications (WGDs) have long been proposed as evolutionary facilitators of biological complexity and diversification. Ancient WGDs occurred deep in the evolutionary history of both plants and vertebrates, but appear to be rare in invertebrates. However, it is unclear whether this reflects genuine scarcity...
T. Lewin, Dearbhaile Casey, Yi-Jyun Luo et al.· bioRxiv· 0 citations
This work develops an automated and user-friendly pipeline for reconstructing ancestral chromosomes before and after WGD, and uses the conservation of gene content to infer chromosomal rearrangement events in this timeframe.
Łukasz Niezabitowski, Anthony K. Redmond, A. McLysaght· bioRxiv· 0 citations
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