Author

Anthony P. Green

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Open access Jul 2026

Protein-confined imidazolium intermediates enable diverse biocatalytic C–C and C–N bond formations

Developing enzymatic strategies to selectively construct C–C and C–heteroatom bonds is a major objective in modern biocatalysis. Here we combine genetic code reprogramming and laboratory evolution to establish a family of allylic transferase enzymes that can achieve a remarkable breadth of chemistry, enabling the gener...

Zachary Birch-Price, A. E. Hutton, Fei Zhao et al. · Nature Catalysis · 1 citation

Open access Aug 2026

Discovery and evolution of an (R)-selective transaminase for production of sitagliptin

R reverse screening as an effective approach for evolving transaminases toward sterically hindered substrates is validates reverse screening as an effective approach for evolving transaminases toward sterically hindered substrates and highlights RTA-223 as a promising candidate for further biocatalyst development.

Matthew Treadell, Gareth R E Surman, G. Ford et al. · RSC Chemical Biology · 0 citations