Author

A. Desiderio

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Open access Oct 2026

Methylglyoxal hampers the angiogenic capacity of human retinal endothelial cells modifying cell transcriptome with the contribution of NRSF/REST

The functional impairment of retinal microvascular cells is an early and central event in diabetic retinopathy (DR). Methylglyoxal (MGO), the most reactive precursor of advanced glycation end products (AGEs), has been implicated in vascular injury and neuro-retinal dysfunction. Its direct effects on retinal endothe...

M. Aprile, C. Nigro, Caterina Perfetto et al. · Frontiers in Cell and Develo... · 0 citations

Open access Sep 2026

Adipose tissue dysfunction in obesity and type 2 diabetes: the role of DNA methylation linking adipogenesis to metabolic disease

Adipose tissue plasticity, sustained by the recruitment and differentiation of adipocyte precursor cells (APCs), is a key determinant of metabolic health. Failure of this adaptive program, rather than fat mass per se, represents an early contributing factor in the progression toward insulin resistance (IR) and type 2...

F. Zatterale, Rosy D'Agostino, P. Florese et al. · Cell & Bioscience · 0 citations

Open access Jul 2026

Blood-Based DNA Methylation Models Improve Short-term Cardiovascular Risk Stratification in Individuals With Type 2 Diabetes

The DNAm-based models generated may improve risk stratification for short-term cardiovascular events in individuals with T2DM, providing a promising approach to refine identification of those at increased risk of MACE.

M. Longo, Antonella Desiderio, M. Masulli et al. · Diabetes Care · 0 citations