A Dictyostelium discoideum Cell-Based Biosensor Reveals Capsule-Associated Virulence Phenotypes in Hypervirulent Klebsiella pneumoniae.
A proof-of-concept cell-based biosensing framework using the social amoeba Dictyostelium discoideum to detect capsule-associated virulence phenotypes in the model hvKp strain SGH10 is established, showing that loss of capsule production strongly reduces mucoviscosity, zebrafish lethality, resistance to amoebal predatio...