A low-crosslinking hydrogel integrating prodrug nanoparticles modulates neuroinflammation and ECM deposition for enhanced spinal cord regeneration.
Spinal cord injury (SCI) causes pathological extracellular matrix (ECM) deposition and tissue stiffening, impeding axonal regeneration and disrupting homeostasis. Galardin-mediated inhibition of matrix metalloproteinases reduces ECM deposition and promotes recovery, but systemic administration fails to adequately addre...