Ao-Qian Xu

Lactylation‐Driven PROS1‐TYRO3‐CARF Signaling Promotes Therapy‐Induced Senescence Escape and Radioresistance in Meningioma

ABSTRACT Radiotherapy is a major treatment for meningioma, but radioresistance remains a key obstacle to durable disease control. Here, we show that escape from therapy‐induced senescence (TIS) is a hallmark of radioresistant meningioma cells and identify a novel glycolysis‐H3K27 lactylation‐PROS1‐TYRO3‐CARF axis under...