Perillaldehyde alleviates Parkinson's disease via the gut microbiota-5-methyltetrahydrofolate-homocysteine methylation axis.
BACKGROUND Gut microbiota dysbiosis is critically involved in the pathogenesis of Parkinson's disease (PD), yet therapeutic strategies targeting the gut-brain axis remain underexplored. Perillaldehyde (PAH), a natural monoterpene aldehyde primarily extracted from Perilla frutescens, exhibits significant neuroprotective...