Aug 2026
TIF1γ regulates stability of regulatory T cells during inflammation
It is shown that TIF1γ-deficient Treg cells lose Foxp3 expression and acquire effector phenotypes in a cell-intrinsic manner upon inflammatory challenge, and TIF1γ is identified as a critical regulator of Treg cell stability that restrains β-catenin–TCF7 signaling.
Eugenio Contreras-Castillo, Jesús Daniel Zambrano-Romero, H. N. Núñez-Martínez et al.
· Nature Immunology · 1 citation