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Author

Arani Chanda

2 papers indexed here

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Open access Sep 2026

Mechanistic Insights into Poloxamer 188-Mediated Stabilization of AAV8 Capsids Using Coarse-Grained Molecular Dynamics.

PURPOSE Aggregation of adeno-associated virus (AAV) during manufacturing and storage remains a challenge in gene therapy formulation. This study evaluates how varying Poloxamer188 (P188) concentrations affect the structural stability and aggregation behavior of two full AAV8 capsids. METHODS Coarse-grained molecular...

Leila Sharifi, Jahanbakhsh Ghasemi, Leo Santisi et al. · 0 citations
Open access Aug 2026

Kinetics, thermodynamics, and mechanisms of PMO interactions from computational molecular modeling

Using solution viscosity measurements combined with computational molecular modeling, interactions of therapeutic 22-mer, 25-mer, and 30-mer PMOs in concentrated solutions are explored, identifying weak preferential functional group interaction patterns that underlie thermodynamic stability.

Ying Chou, Igor Novikov, Daniel Pierson et al. · 1 citation

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