Author

Ariel Afek

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Open access Sep 2026

Reciprocal, methylation-dependent binding of Zfp57 and Gzf1 safeguards Dlk1-Dio3 imprinting during developmental reprogramming

Genomic imprinting secures parent-specific gene expression through differential DNA methylation at imprinted control regions (ICRs). However, how unmethylated alleles resist de novo methylation remains unclear. Using an allelic Dlk1-Dio3 ICR methylation reporter and genome-wide loss-of-function screening, we identify t...

Arik Toren, Liron Hoffman, Irina Miodownik et al. · Nature Communications · 0 citations

Open access Aug 2026

EpiBinder: A Multimodal Framework for Cell-Type-Specific Prediction and Interpretation of Transcription Factor Binding

EpiBinder is presented, a multimodal deep-learning framework for cell-type-specific prediction of TF binding that jointly models DNA sequence with base-resolution epigenetic information, including cytosine methylation from whole-genome bisulfite sequencing and chromatin accessibility from DNase I hypersensitivity data.

R. Solozabal, Albert Baichorov, Irina Miodownik et al. · bioRxiv · 0 citations