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Author

Aristeidis Sotiras

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Open access Sep 2026

Taming dimensionality in big neuroimaging data: Efficient orthonormal projective NMF via stochastic learning and data compression

Abstract Large-scale neuroimaging datasets present remarkable opportunities for advancing our understanding of human brain structure and function. Data-driven pattern analysis methods such as Orthonormal Projective Non-negative Matrix Factorization (opNMF) are particularly well suited to uncover multivariate relationsh...

Abdalla Bani, Min-Ha Sung, Thomas W Earnest et al. · 0 citations
Open access Aug 2026

Regional Cerebrospinal Fluid Motility as a Key Determinant of Soluble Amyloid-β Levels and Kinetics

Effective CSF motility is identified as an important physiological determinant of soluble Aβ levels in plasma and CSF, linking regional CSF dynamics to in vivo Aβ transport and turnover, with potential relevance to cerebral amyloid angiopathy and Alzheimer’s disease.

H. Hosseini, A. Sotiras, Chihiro Sato et al. · 0 citations

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