Discovery of PIM-1 kinase inhibitors from marine natural products through machine learning and structure-based screening
PIM-1 kinase, a serine/threonine kinase implicated in several cancers, has emerged as a promising yet underexplored target for anticancer therapy. This study aimed to identify the potential of PIM-1 inhibitors from marine natural products by integrating machine learning (ML)-based quantitative structure-activity re...