Author

Arnaud Monteil

2 papers indexed here

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Review Open access Oct 2026

An AI-Enabled Translational Drug Discovery Framework for NALCN Channelopathy: From High-Throughput Screening to Therapeutic Candidate

Background More than 90% of rare diseases lack an approved therapy, partly reflecting economic barriers in developing treatments for small patient populations. A common bottleneck is costly and resource-intensive hit-to-lead prioritization. Congenital contractures of the limbs and face, hypotonia, and developmental del...

N. Thongsepee, Jeremy A. Tanner, Srikanth R. Polusani et al. · bioRxiv · 0 citations

Open access Oct 2026

Deletion of the sodium leak channel NALCN in dopamine neurons alters D2R-mediated signalling and psychostimulant responsiveness.

Midbrain dopamine (DA)-neurons are slow pacemakers that continuously fire action potentials, maintaining basal extracellular DA levels in target regions. The sodium leak channel NALCN has been identified as a key contributor in the pacemaker control of these neurons. However, the consequences of a disrupted DA pacemake...

Angelina Rogliardo, T. Le Borgne, A. Gulmez et al. · Journal of Physiology · 0 citations