Abstract B096: Immune and stromal features of durable complete response to radiation and dual immune checkpoint blockade in pancreatic cancer
Microsatellite stable (MSS) pancreatic ductal adenocarcinoma (PDAC) is refractory to immune checkpoint blockade, reflecting an immunosuppressive stroma, impaired lymphocyte trafficking, and low neoantigen burden. We conducted a single-arm phase II trial (NCT04361162) combining nivolumab, ipilimumab and radiation ther...