Author

Arne Van der Vreken

2 papers indexed here

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Review Open access Sep 2026

T cell senescence and exhaustion: molecular mechanisms and immune rejuvenation for cancer immunotherapy

T cell exhaustion and T cell senescence constitute distinct yet partially overlapping differentiation states that collectively constrain T cell functionality. T cell exhaustion arises under conditions of chronic antigen exposure and is characterised by a progressive, hierarchical loss of effector capacity, sustained ex...

Lauren van den Broecke, Arne Van der Vreken, Fenja Watté et al. · Signal Transduction and Targ... · 1 citation

Open access Aug 2026

Latent effector T cells mediate immunotherapy responses in the bone marrow microenvironment.

TFiT (tumor-reactive features in T cells), a transcriptional classifier that identifies tumor-reactive T cells and stratifies immunotherapy, but not chemotherapy, response across independent MM and AML cohorts, supporting its specificity for T cell-mediated tumor control.

N. Kehl, T. Wagner, Simon Steiger et al. · Cancer Cell · 1 citation