Author

Arnold J. M. Driessen

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Open access Sep 2026

Functional mapping and engineering of the Sec translocon unlocked by a cell-free system

Almost all membrane proteins are inserted or translocated across membranes by the universally conserved Sec translocon. Despite its central role, experimental access to Sec function has remained limited. Here, we present ProSecCO (Protein Secretion in Cell-free via synthetic Operons), which is a cell-free protein synth...

M. Meier, Scott A. Scholz, Leo von Bank et al. · Science Advances · 2 citations

Aug 2026

Hydrophobicity and signal sequence binding to the Sec complex: A single molecule biophysical perspective.

The Sec61 complex plays a critical role in protein translocation into the endoplasmic reticulum (ER), enabling the passage of soluble proteins into the lumen and the lateral insertion of membrane proteins. The Sec complex, comprising Sec61, Sec63, Sec62, and other auxiliary proteins, is especially important for the tra...

W. Sánchez, Luka Robeson, Hilda M. Alfaro-Valdés et al. · Biochemical and Biophysical... · 0 citations