Author

A. D. de Ru

2 papers indexed here

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Aug 2026

Immunoglobulin constant domains as targets for T-cell receptor-based treatment of multiple myeloma.

Despite major progress with chimeric antigen receptor (CAR) T-cell therapy, multiple myeloma (MM) remains largely incurable, and most patient relapse. To broaden therapeutic options and overcome antigen escape, we explored T-cell receptor (TCR)-based targeting of intracellular antigens derived from immunoglobulin (Ig)...

M. Meeuwsen, A. Wouters, Johannes C. Wellershoff et al. · Blood · 0 citations

Open access Jul 2026

Identification of cellular intermediates unveils unique enzymes for flagellar glycan biosynthesis in Clostridioides difficile.

Glycosylation of bacterial surface proteins, such as flagellin (FliC), is important for their function and is often involved in virulence of pathogens. Glycans can be further modified by so-called postglycosylation modifications (PGMs), often resulting in exclusive molecular structures. In Clostridioides difficile, a u...

P. Hensbergen, Bob van Puffelen, Nina Musch et al. · Proceedings of the National... · 0 citations