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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

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Arthur A. Levin

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Open access Aug 2026

Neutral Backbone Modifications Enhance the Pharmacokinetics and Biodistribution of Antibody–Oligonucleotide Conjugates with High Drug-to-Antibody Ratios

Antibody–oligonucleotide conjugates (AOCs) enable targeted delivery of small interfering RNAs (siRNAs) by coupling them to antibodies for receptor-mediated uptake, enhancing tissue specificity and therapeutic potential. A key determinant of AOC performance is the drug-to-antibody ratio (DAR), which influences pharmacok...

Michael Cochran, S. Nallagatla, G. Iacono et al. · 0 citations

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