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Author

Arthur A. Melo

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Open access Sep 2026

Cryo-EM Structures of Infectious Low-Twist α-Synuclein Filaments in Lewy Bodies

α-Synuclein (aSyn) aggregation within Lewy bodies underlies Parkinson’s disease and associated dementias. These aggregates are often comprised of amyloid filaments, most of which appear untwisted or have extremely low twist, complicating high-resolution structural determination by cryogenic electron microscopy (cryo-EM...

Nicholas L. Yan, Mylan Mayer, Arthur A. Melo et al. · 0 citations
Open access Aug 2026

Cofactor-Free Tau Filaments Are Dynamic and Undergo Structural Evolution Driven by Thermodynamic Control

Environmental factors, such as mechanical stress and/or polyanions, play an important role in promoting the thermodynamic stability of otherwise dynamic tau fibrils, and it is speculated that, in patients, such factors might contribute to the maturation of disease-specific conformers.

Wyatt C. Powell, Nicholas L. Yan, Eric Tse et al. · 0 citations

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