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Author

Arthur Chow

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Open access Sep 2026

Sequence and structural determinants of efficacious de novo chimaeric antigen receptors

This framework synthesizes generative protein design workflows to screen 1,758 newly designed protein binders targeting BCMA, CD19 and CD22 for efficacy in scalable protein-binding, T-cell activation and in vivo killing assays, and develops computational and experimental heuristics to overcome limitations.

Arthur Chow, Ho-Yin Chu, Ruo-Fan Li et al. · 5 citations

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