Author

Arti Dhar

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Aug 2026

Nesfatin-1 Deficiency Exacerbates Calcium Oxalate Monohydrate–Induced Cellular Injury in Renal Epithelial Cells

Calcium oxalate monohydrate (COM) crystals are major contributors to nephrolithiasis-associated renal tubular injury, primarily through mechanisms involving oxidative stress, inflammation, apoptosis, and epithelial–mesenchymal transition (EMT). While nesfatin-1 is known for its antioxidant and cytoprotective actions,...

G. Lahane, Arti Dhar · ACS Pharmacology & Trans... · 0 citations

Review Open access Sep 2026

Exploiting DNA damage tolerance for precision oncology.

Unresolved DNA lesions trigger replication stress, forcing cancer cells to hijack DNA damage tolerance (DDT) networks, specifically translesion synthesis (TLS) and template switching, to sustain replication. While DDT prevents lethal fork collapse, error-prone TLS drives mutagenesis, tumor evolution, chemoresistance an...

Audesh Bhat, G. Lahane, R. Pandita et al. · Trends in Cancer · 0 citations

Aug 2026

Calcium oxalate-induced renal epithelial cell injury is mediated by receptor-interacting serine/threonine kinase 2 (RIPK2).

Preliminary data from the previously conducted in vivo CaOx mouse model study confirmed the CaOx-induced RIPK2 upregulation and strongly supports the involvement of RIPK2 in CaOx-induced renal cell damage.

G. Lahane, Arti Dhar, Audesh Bhat · Biochemical Pharmacology · 0 citations