Discovery and Biological Characterization of 1-[4-(2-Difluoromethoxyphenyl)-5-methylthiazol-2-yl]-3-(naphthalen-1-yl)urea (DFMNTU): A Novel Thiazolyl-Urea Chemotype Targeting Yellow Fever Virus and Host Casein Kinase 2 (CK2).
Yellow fever virus (YFV) is a re- emerging mosquito- borne flavivirus that causes severe hemorrhagic fever with high case- fatality rates. Due to vaccine contraindications, incomplete immunization coverage, and the absence of approved specific antivirals, host- directed drug discovery targeting cellular machinery explo...